ABSTRACT
Background: Gastroesophageal reflux disease [GERD] is one of the most common gastrointestinal problems worldwide
The aim of this study was to evaluate the clinical spectrum, prevalence, and some of the variables that are supposed to be the risk factors of this chronic disorder
Methods: This population- based cross-sectional study was conducted in a one-stage randomized clustered sample of adult inhabitants in Kerman city in 2011-2012. A total of 2265 subjects with age range of 15-85 years were enrolled
Face to face interview was performed for all the subjects. GERD was defined as at least weekly heart burn and/or acid regurgitation during the past year. Association of GERD with factors like demographic variables, medical condition, diet and life habits were analyzed
Results: A total of 2265 subjects including 988 [43.8%] male and 1275 [56.3%] female patients were evaluated. The prevalence of GERD was 28%. The prevalence was higher in female patients and with aging. There was also a significant association between GERD and the following risk factors: lower educational level [p 0.000l], higher body mass index [p =003], presence of depression [p<0.000 1], and anxiety [p <0=0001]
Conclusion: GERD as a common disorder in our region was seen more in elderly and female patients and was associated with some anthropometric, metabolic, medical conditions, and behavioral habits
ABSTRACT
Menetrier's disease is a rare cause of hypertrophic gastropathy that is usually confined to the gastric body and fundus. It is characterized by giant rugae, hypoalbuminemia, and foveolar hyperplasia. Here we report the case of a 26-year-old woman who presented with epigastric pain, postparandial nausea-vomiting, and weight loss. Paraclinic evaluation revealed hypoalbuminemia and hypochromic microcytic anemia. Gastroscopy and barium meal study showed diffuse polypoid, nodular lesions that affected the entire stomach, invaginating into the duodenum, leading to partial duodenal obstruction. The histologic, radiologic and endoscopic findings fulfilled the diagnosis of Menetrier's disease. To the best of our knowledge, gastroduodenal intussusception by Menetrier's disease has been rarely described in the literature
Subject(s)
Humans , Female , Intussusception , Duodenal Diseases , Stomach Diseases , Gastroscopy , BariumABSTRACT
H. pylori is a human pathogen that colonizes the epithelium of the stomach. The host immune response may influence the disease process, where cytokines play important roles in the development of disease. In this study, the concentrations of selected cytokines in the gastric antrum and stomach body mucosa and also in the serum were evaluated. Eighty patients according to their rapid urease test were divided into two groups: H. pylori positive [n=39] and H.pylori-negative [n=41]. The concentrations of cytokines in biopsies and serum were determined by ELISA method. The mean TNF-alpha and IFN-gamma levels in the infected group were significantly higher than that of uninfected patients. In contrast, IL-10 level in most patients was undetectable. The mean antral of stomach TNF-alpha and IFN-gamma levels were significantly higher than that of the stomach body. IFN-gamma serum level showed positive correlation with antrum and stomach body levels, whereas no correlation was found in TNF-alpha in different samples. Higher levels of TNF-alpha and IFN-gamma in antral indicate that the colonization of bacteria in the antrum may be higher than stomach body [culture results from two sites support this statement]. Increased serum level of IFN-gamma indicates the activation of circulating-T cells against infection. Induced H. pylori-related TNF-alpha is concentrated is gastric mucosa and this pathogen does not cause any significant change in the serum level of this cytokine. Therefore H. pylori by inducing certain inflammatory cytokines but not IL-10 may contribute the process of disease development